![]() In an effort to understand the molecular basis of pathogen gene expression differences, we isolated native E. ![]() The adaptive response of the pathogen to different host environments entails switch of gene expression regulated at the level of transcription, possibly by altering RNA polymerase activity. chaffeensis originating from its tick and vertebrate host cells. In recent studies, we demonstrated significant host-specific differences in protein expression in E. chaffeensis and many related tick-borne rickettsial pathogens adapt and persist in vertebrate and tick hosts remain largely unknown. Ehrlichia chaffeensis is a tick-transmitted rickettsial pathogen responsible for an important emerging disease, human monocytic ehrlichiosis.
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